منابع مشابه
Influenza vaccines: present and future.
The impact of influenza on individuals and on society remains underappreciated. Up to 20% of the population may develop influenza in any given year, and epidemics of influenza are responsible — on average — for 20,000 deaths per year in the US. In some epidemics, this number may climb to more than 40,000 deaths, with over 300,000 influenza-related hospitalizations in a single winter season (1)....
متن کاملUniversal influenza vaccines: Shifting to better vaccines
Influenza virus causes acute upper and lower respiratory infections and is the most likely, among known pathogens, to cause a large epidemic in humans. Influenza virus mutates rapidly, enabling it to evade natural and vaccine-induced immunity. Furthermore, influenza viruses can cross from animals to humans, generating novel, potentially pandemic strains. Currently available influenza vaccines i...
متن کاملInfluenza vaccines Richard
1. Abstract 2. Introduction 2.1. Mechanisms of influenza virus evolution 2.2. Resurgence of influenza vaccinology 3. Current influenza vaccines 3.1. Inactivated vaccines 3.2. Live attenuated vaccines 3.3. Limitations of current influenza vaccine strategies 4. Reverse genetics 4.1. Creation of high-growth reassortant vaccine strains 4.2. Other uses of reverse genetics in influenza vaccines 4.3. ...
متن کاملTowards universal influenza vaccines?
Vaccination is the most cost-effective way to reduce the considerable disease burden of seasonal influenza. Although seasonal influenza vaccines are effective, their performance in the elderly and immunocompromised individuals would benefit from improvement. Major problems related to the development and production of pandemic influenza vaccines are response time and production capacity as well ...
متن کاملToward improved influenza vaccines.
Influenza takes a large toll on human health, particularly in the elderly population. The current unadjuvanted trivalent inactivated influenza vaccines (TIVs) are notorious for modest-to-dismal efficacy among elderly individuals. Protection by TIV is limited largely to the 3 or 4 strains chosen for each influenza season. The drifts in circulating strains mean that annual receipt of TIV is recom...
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ژورنال
عنوان ژورنال: Expert Review of Vaccines
سال: 2012
ISSN: 1476-0584,1744-8395
DOI: 10.1586/erv.12.65